Health

Laboratory lungs were successfully transplanted into experimental animals

Scientists in the US created lungs in the lab and announced that were successfully and without complications transplanted into pigs . This is an encouraging advance in the field of organ and tissue transplantation and transplantation. This is the first time a laboratory instrument has been transplanted into a large animal and it has survived.

All the animals that received the bio-artificial lung remained healthy for up to two months. Already two weeks after transplantation, the laboratory lung had created the necessary blood vessel network that allowed it to survive in the body, which prevented the risk of pulmonary edema. No graft was discarded, although the animals did not take immunosuppressive drugs.

Researchers at the University of Texas Medical School at Galveston, led by Professor Joan Nichols, published the publication in the American Medical Journal “Science Translational Medicine”.

“The number of people with severe lung problems has risen globally, while the number of organs available for transplantation has declined. Our ultimate goal is ultimately to provide new choices for the many people waiting for a transplant, “Nicole said.

The same research team was the first in 2014 to have successfully created human lungs in the laboratory through biomedical technology. Now, American scientists have gone one step further by going through laboratory lung transplantation.

On a “scaffold” in the laboratory, the appropriate cells were placed, which, after a 30 day culture, created a new lung.

But even after two months, the laboratory lung was not mature enough to supply the animal with oxygen. Future studies will consider the survival of animals in the longer term. Scientists believe that if they secure adequate funding for their research they will have managed to transplant laboratory lungs into humans in five to ten years from today.

Lung transplantation is used to treat various conditions such as cystic fibrosis and emphysema. Often, in addition to long waiting for grafting, the donor lung has to adjust to the size of the patient and the latter needs to take immunosuppressive medications to reduce the risk of miscarriage of the foreign organ.

Laboratory lungs that will have been created by the patient’s own cells will allow doctors to avoid many of these obstacles in the future.