Nanochip immediately transfers new DNA or RNA to the skin cells, thus changing their function and causing the tissue and organs to regenerate. The small coin size device can recreate almost every kind of cell within the patient’s body without first having the skin cells turned into pluripotent stem cells and then into other specialized cells. The transformation is done directly from skin to specialized cells.
The collaborating researchers at the Ohio State University Medical College and Engineering College, led by professors Tsan Senn (specialist in regenerative medicine) and James Lee (chemist and biologist) respectively, published the publication in Nanotechnology Magazine “Nature Nanotechnology” .
“Using a new nanopatch technology, injured or dysfunctional instruments can be replaced. We have shown that the skin is a fertile ground where we can develop the components of any organ that has a problem, “said Sen.
At present, the method has been successfully tested in experimental animals. Thanks to the new chip, scientists have succeeded in reprogramming skin cells to turn into blood vessel cells in legs of severely wounded animals where blood was no longer circulating. Within one week, new vessels were born and in the second week blood circulation was restored and the injured lower limbs were saved.
The researchers also reprogramed dermal cells with nanochip to turn them into nerve cells in the animal’s body. Then these new nerve cells were implanted in their brains and helped the animals recover after stroke. “Although it is hard to imagine, it is feasible and ‘works’ in 98% of cases. With this technology, we can transform skin cells into components of each instrument with a single touch. The whole procedure takes less than a second and is non-invasive, “Dr. Shen said.
The new technology (Tissue NanoTransfection – TNT) is based, on the one hand, on the microscopic chip that carries the biological “charge” to the body, and on the other on the “charge” itself that causes the cells to be transformed from one cell type to another. The patient almost does not feel the instant functioning of the nanoparticle as it touches him, and he does not need to take immunosuppressive drugs.
Researchers plan to start clinical trials in humans by 2018. They hope their method will be exploited in many cases today, requiring complicated surgeries, neurodegenerative diseases (Alzheimer’s, Parkinson’s) and early aging.