The tiny appendix may be a hidden source of risk for the onset of Parkinson’s disease and its removal reduces by 25% the risk of this incurable neurological disorder, according to a new international scientific research, the largest of its kind to date .
It is the first time that scientists associate Parkinson to the instrument body, which appears to act as a ‘reservoir’ for abnormal neuronal proteins (alpha-synuclein) associated with the onset and exacerbation of disease. People who have surgery removal of appendicitis (the appendix has inflammation) have a reduced risk of developing Parkinson’s by 19% to 25%, provided that the intervention is done early in life, several years before the onset of the first symptoms of the disease . If the surgery is done after Parkinson’s has occurred, there is no benefit in the progression of the disease. On the other hand, timely removal of appendicitis delays the diagnosis of Parkinson’s in patients by 3.6 years on average.
The researchers, led by assistant professor Vivian illustrious Research Institute Van ‘Adel Michigan who analyzed data for about 1.7 million. And made the notice published in the American medical journal «Science Translational Medicine», confirmed that the gut and the immune system plays a role in triggering Parkinson’s disease.
“Our findings show the appendicular appendix as the region of origin of Parkinson’s and open a new path for alternative therapeutic strategies that will harness the role of the gastrointestinal system in the development of the disease. Although the appendix has gained a reputation of being redundant, in fact plays an important role in our immune system, regulating the bacteria in our gut and, is playing a role in Parkinson’s disease.
The researchers unexpectedly discovered the abnormal form of the α-synuclein protein, not only in the appendixes of Parkinson’s patients, but also in healthy individuals. Until now, scientists believed that toxic a-synuclein – the most hallmark of Parkinson’s – was present only to patients.
Parkinson’s are more common among rural residents than in towns, and scientists suspect this is due to the more frequent exposure of pesticides to insecticides. There are no reliable tests to diagnose the disease, which is often diagnosed at a more advanced stage when motor symptoms such as tremors or muscular stiffness appear, and in the meantime, advanced brain damage has occurred.